15 days in Southern Italy, Greece & Istanbul Itinerary

Often referred to as the gem of the Amalfi Coast, Positano remains one of southern Italy's most sought-after vacation locales, thanks to its hillside location and picturesque, pastel buildings.

Your cultural itinerary includes sights like Duomo di Sant'Andrea and Museo della Carta. Your itinerary includes some good beach time at Fornillo and Arienzo Beach Club, Positano. Explore Positano's surroundings by going to Villa Rufolo (in Ravello) and Amalfi (Centro Storico & Cloister del Paradiso). And it doesn't end there: take a tour by water with Boat Tours & Water Sports, look for gifts at Nana' Positano, trek along Walk of the Gods, and contemplate the long history of Church of Santa Maria Assunta.

For reviews, more things to do, where to stay, and more tourist information, refer to the Positano online trip planner.

Detroit, USA to Positano is an approximately 17-hour combination of flight, train, and ferry. Due to the time zone difference, you'll lose 6 hours traveling from Detroit to Positano. Traveling from Detroit in April, things will get somewhat warmer in Positano: highs are around 22°C and lows about 15°C. You will have some time to spend on the 14th (Fri) before leaving for Oia.

Every day hundreds of visitors come to Oia just to experience its sunsets.

On the 15th (Sat), do a tasting at Santo Winery, then examine the collection at Cultural Village, and then step into the grandiose world of Castelli of Pyrgos. Get ready for a full day of sightseeing on the 16th (Sun): relax and rejuvenate at some of the best spas, do a tasting at Domaine Sigalas, then look for gifts at Atlantis Books E.E., and finally take in the exciting artwork at Mnemossyne Gallery.

To find ratings, photos, reviews, and more tourist information, you can read our Oia trip planner.

You can do a combination of ferry, flight, and bus from Positano to Oia in 10 hours. Other options are to do a combination of car and ferry; or do a combination of taxi, train, bus, and ferry. You'll lose 1 hour traveling from Positano to Oia due to the time zone difference. Expect a daytime high around 23°C in April, and nighttime lows around 15°C. Finish your sightseeing early on the 16th (Sun) so you can travel to Mykonos Town.

A holiday in Mykonos Town offers a chance to relax on picturesque beaches and explore a labyrinth of charming streets lined with traditional white houses.

Kick off your visit on the 17th (Mon): wander the streets of Little Venice, make a trip to The Windmills (Kato Milli), and then take in the architecture and atmosphere at Agios Nikolakis Church. Here are some ideas for day two: see some colorful creatures with Mykonos Diving Center, then enjoy the sand and surf at Paradise Beach, and then soothe aching muscles at some of the top local wellness centers.

To find reviews, photos, ratings, and other tourist information, refer to the Mykonos Town road trip planning app.

You can do a combination of taxi and ferry from Oia to Mykonos Town in 3 hours. Alternatively, you can do a combination of taxi and flight. April in Mykonos Town sees daily highs of 22°C and lows of 16°C at night. Finish up your sightseeing early on the 18th (Tue) so you can catch the flight to Athens.

One of the world's most ancient cities, Athens remains Europe's undisputed historical and cultural capital.

Start off your visit on the 19th (Wed): pause for some serene contemplation at Church of Kapnikarea, then admire the masterpieces at Museum of Cycladic Art, then take in the spiritual surroundings of Temple of Hephaestus, and finally pause for some photo ops at Erechtheion. On your second day here, wander the streets of Plaka, get engrossed in the history at Acropolis Museum, and then kick back and relax at Asteras Glyfada Beach.

To see traveler tips, where to stay, maps, and other tourist information, refer to the Athens trip planner.

Traveling by flight from Mykonos Town to Athens takes 2.5 hours. Alternatively, you can fly; or do a combination of ferry and taxi. Expect a daytime high around 24°C in April, and nighttime lows around 15°C. Wrap up your sightseeing on the 20th (Thu) to allow time to fly to Istanbul.

A physical and cultural bridge between Europe and Asia, the transcontinental city of Istanbul serves as a living reminder of the Roman, Byzantine, and Ottoman empires.

Appreciate the collections at Topkapi Palace and Galata Tower. Get some historical perspective at Hagia Sophia Mosque and Suleymaniye Cami . There's much more to do: contemplate in the serene atmosphere at Sultan Ahmed Mosque, admire the striking features of Eyüp Sultan Mosque, stop by Motif Collection, and browse the eclectic array of goods at Kapali Carsi.

For photos, more things to do, other places to visit, and tourist information, you can read our Istanbul holiday app.

Traveling by flight from Athens to Istanbul takes 4.5 hours. Alternatively, you can drive; or take a bus. Traveling from Athens to Istanbul, you'll lose 1 hour due to the time zone difference. In April, Istanbul is a bit cooler than Athens - with highs of 20°C and lows of 9°C. You'll have a few hours on the 24th (Mon) to wrap things up before traveling home.