21 days in Guatemala & Cancun Itinerary
Created using Klarna Trips trip itinerary builder
Start: Indianapolis, United States
Fly
1
Antigua, Guatemala
— 4 nights
Shuttle
2
Chichicastenango, Guatemala
— 2 nights
Shuttle
3
Huehuetenango, Guatemala
— 1 night
Drive
4
Todos Santos, Guatemala
— 1 night
Drive
5
San Marcos La Laguna, Guatemala
— 1 night
Fly
6
Flores, Guatemala
— 3 nights
Fly
7
Guatemala City, Guatemala
— 2 nights
Fly
8
Cancun, Mexico
— 6 nights
Fly
End: Indianapolis, United States
Sat, Jan 21 - Fri, Feb 10
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Antigua, Guatemala — 4 nights

Arco de Santa Catalina and Cathedral de Santiago will appeal to history buffs. Step off the beaten path and head to ChocoMuseo La Antigua and Cerro de la Cruz. And it doesn't end there: pause for some serene contemplation at Iglesia de La Merced, admire the masterpieces at Casa Santo Domingo Museums, explore the ancient world of Convento de las Capuchinas, and steep yourself in history at Iglesia de San Francisco El Grande.
To see photos, more things to do, maps, and other tourist information, go to the Antigua day trip planner.
Indianapolis, USA to Antigua is an approximately 9.5-hour flight. You can also drive; or do a combination of train, bus, car, and taxi. Due to the time zone difference, you'll gain 1 hour traveling from Indianapolis to Antigua. Expect much hotter temperatures when traveling from Indianapolis in January; daily highs in Antigua reach 74°F and lows reach 53°F. Finish up your sightseeing early on the 25th (Wed) so you can catch the shuttle to Chichicastenango.
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To see photos, more things to do, maps, and other tourist information, go to the Antigua day trip planner.
Indianapolis, USA to Antigua is an approximately 9.5-hour flight. You can also drive; or do a combination of train, bus, car, and taxi. Due to the time zone difference, you'll gain 1 hour traveling from Indianapolis to Antigua. Expect much hotter temperatures when traveling from Indianapolis in January; daily highs in Antigua reach 74°F and lows reach 53°F. Finish up your sightseeing early on the 25th (Wed) so you can catch the shuttle to Chichicastenango.
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Chichicastenango, Guatemala — 2 nights
Chichi
Start off your visit on the 26th (Thu): tour the pleasant surroundings at Laguna Lemoa and then explore the different monuments and memorials at Chichi Cemetery. On the 27th (Fri), you'll have a packed day of sightseeing: contemplate the long history of Pascual Abaj, then examine the collection at Museo de Mascaras Ceremoniales, and then pause for some serene contemplation at Santo Tomas Church.
To find photos, ratings, and other tourist information, go to the Chichicastenango itinerary maker.
You can take a shuttle from Antigua to Chichicastenango in 2 hours. Alternatively, you can drive; or take a bus. Traveling from Antigua in January, you can expect nighttime temperatures to be a bit cooler in Chichicastenango, with lows of 40°F. Finish your sightseeing early on the 27th (Fri) to allow enough time to take a shuttle to Huehuetenango.
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To find photos, ratings, and other tourist information, go to the Chichicastenango itinerary maker.
You can take a shuttle from Antigua to Chichicastenango in 2 hours. Alternatively, you can drive; or take a bus. Traveling from Antigua in January, you can expect nighttime temperatures to be a bit cooler in Chichicastenango, with lows of 40°F. Finish your sightseeing early on the 27th (Fri) to allow enough time to take a shuttle to Huehuetenango.
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Huehuetenango, Guatemala — 1 night
Kick off your visit on the 28th (Sat): take some stellar pictures from Mirador Juan Dieguez Olaverri and then explore the ancient world of Ruinas de Zaculeu.
To see other places to visit, photos, ratings, and more tourist information, read Huehuetenango trip itinerary planner.
Traveling by shuttle from Chichicastenango to Huehuetenango takes 2 hours. Alternatively, you can drive; or take a bus. Traveling from Chichicastenango in January, expect nights in Huehuetenango to be about the same, around 42°F, while days are a bit warmer, around 76°F. Finish your sightseeing early on the 28th (Sat) to allow enough time to travel to Todos Santos.
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To see other places to visit, photos, ratings, and more tourist information, read Huehuetenango trip itinerary planner.
Traveling by shuttle from Chichicastenango to Huehuetenango takes 2 hours. Alternatively, you can drive; or take a bus. Traveling from Chichicastenango in January, expect nights in Huehuetenango to be about the same, around 42°F, while days are a bit warmer, around 76°F. Finish your sightseeing early on the 28th (Sat) to allow enough time to travel to Todos Santos.
Find places to stay Jan 27 — 28:
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Todos Santos, Guatemala — 1 night

Start off your visit on the 29th (Sun): stop by HispanoMaya.
For photos, maps, reviews, and other tourist information, use the Todos Santos online tour planner.
The Route module can help you plan travel from Huehuetenango to Todos Santos. Expect slightly colder weather when traveling from Huehuetenango in January: highs in Todos Santos hover around 70°F, while lows dip to 40°F. Cap off your sightseeing on the 29th (Sun) early enough to travel to San Marcos La Laguna.
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For photos, maps, reviews, and other tourist information, use the Todos Santos online tour planner.
The Route module can help you plan travel from Huehuetenango to Todos Santos. Expect slightly colder weather when traveling from Huehuetenango in January: highs in Todos Santos hover around 70°F, while lows dip to 40°F. Cap off your sightseeing on the 29th (Sun) early enough to travel to San Marcos La Laguna.
Find places to stay Jan 28 — 29:
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San Marcos La Laguna, Guatemala — 1 night
Start off your visit on the 30th (Mon): relax and rejuvenate at some of the best spas and then view the masterpieces at Galeria Imox.
To find reviews, where to stay, and other tourist information, use the San Marcos La Laguna trip planner.
Explore your travel options from Todos Santos to San Marcos La Laguna with the Route module. Expect a bit warmer weather when traveling from Todos Santos in January: highs in San Marcos La Laguna hover around 76°F, while lows dip to 42°F. Cap off your sightseeing on the 30th (Mon) early enough to catch the flight to Flores.
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To find reviews, where to stay, and other tourist information, use the San Marcos La Laguna trip planner.
Explore your travel options from Todos Santos to San Marcos La Laguna with the Route module. Expect a bit warmer weather when traveling from Todos Santos in January: highs in San Marcos La Laguna hover around 76°F, while lows dip to 42°F. Cap off your sightseeing on the 30th (Mon) early enough to catch the flight to Flores.
Side Trips
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Flores, Guatemala — 3 nights

Visit Tikal and Catedral de Flores for their historical value. You'll explore the less-touristy side of things at Cultural Triangle Yaxha-Nakum-Naranjo National Park and Actún Can. Change things up with a short trip to Dos Pilas in Peten (about 1h 5 min away).
To find photos, maps, other places to visit, and tourist information, read Flores road trip tool.
Fly from San Marcos La Laguna to Flores in 3 hours. Alternatively, you can drive; or take a shuttle. Traveling from San Marcos La Laguna in January, plan for much warmer nights in Flores, with lows around 63°F. Wrap up your sightseeing on the 2nd (Thu) to allow time to fly to Guatemala City.
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To find photos, maps, other places to visit, and tourist information, read Flores road trip tool.
Fly from San Marcos La Laguna to Flores in 3 hours. Alternatively, you can drive; or take a shuttle. Traveling from San Marcos La Laguna in January, plan for much warmer nights in Flores, with lows around 63°F. Wrap up your sightseeing on the 2nd (Thu) to allow time to fly to Guatemala City.
Side Trips
Find places to stay Jan 30 — Feb 2:
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Guatemala City, Guatemala — 2 nights

Guate
On the 3rd (Fri), see the interesting displays at Museo Numismatico de Guatemala, steep yourself in history at Palacio Nacional, and then admire the masterpieces at Casa Mima. Here are some ideas for day two: examine the collection at Museo del Ferrocarril, get a new perspective on nature at Museo Popol Vuh, then explore the world behind art at Museum of Modern Art Carlos Merida, and finally delve into the distant past at Acueducto de Pinula.
To see more things to do, other places to visit, reviews, and tourist information, refer to the Guatemala City trip itinerary maker site.
Traveling by flight from Flores to Guatemala City takes 2.5 hours. Alternatively, you can take a bus; or drive. Traveling from Flores in February, expect Guatemala City to be slightly colder, temps between 76°F and 55°F. Cap off your sightseeing on the 4th (Sat) early enough to catch the flight to Cancun.
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To see more things to do, other places to visit, reviews, and tourist information, refer to the Guatemala City trip itinerary maker site.
Traveling by flight from Flores to Guatemala City takes 2.5 hours. Alternatively, you can take a bus; or drive. Traveling from Flores in February, expect Guatemala City to be slightly colder, temps between 76°F and 55°F. Cap off your sightseeing on the 4th (Sat) early enough to catch the flight to Cancun.
Find places to stay Feb 2 — 4:
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Cancun, Mexico — 6 nights

Explore hidden gems such as Mayan Museum of Cancun and Playa Delfines. Casa de los Venados and Scorpion’s Temple are good opportunities to explore the local culture. You'll find plenty of places to visit near Cancun: Isla Mujeres (Playa El Centro & Punta Sur), Playa del Carmen (Gaston Charo Art Gallery Playa del Carmen & Parque Los Fundadores) and Valladolid (Iglesia de la Candelaria & Iglesia De San Servacio). There's much more to do: glide peacefully along the water with some of the best stand-up paddleboarding in the area, indulge in some personalized pampering at some of the best spas, take in the pleasant sights at Avenida Kukulkan, and take in panoramic vistas at Torre Escenica.
For maps, traveler tips, and tourist information, you can read our Cancun trip planner.
Fly from Guatemala City to Cancun in 5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Guatemala City to Cancun is 1 hour. Traveling from Guatemala City in February, you can expect nighttime temperatures to be somewhat warmer in Cancun, with lows of 68°F. Cap off your sightseeing on the 10th (Fri) early enough to catch the flight back home.
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For maps, traveler tips, and tourist information, you can read our Cancun trip planner.
Fly from Guatemala City to Cancun in 5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Guatemala City to Cancun is 1 hour. Traveling from Guatemala City in February, you can expect nighttime temperatures to be somewhat warmer in Cancun, with lows of 68°F. Cap off your sightseeing on the 10th (Fri) early enough to catch the flight back home.
Side Trips
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Land of Eternal Spring
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Lake Atitlan travel guide
Lake Atitlan, a large volcanic lake, provides the setting for a wealth of interesting Mayan towns and villages. Surrounded by imposing and scenic mountains, the lake forms part of a sprawling national park, rich in wildlife and cultural attractions. The main towns and villages range from touristy gateways to authentic realms of tradition and culture, with charming local markets, rustic architecture, and a laid-back feel. Many of the towns can only be reached by boat, with trips on the lake high on most visitors' Lake Atitlan itineraries.