21 days in Uruguay & Paraguay Itinerary

Created using Klarna Trips South America trip planner
Make it your trip
Fly to Carrasco International /General C L Berisso Airport, Drive to Punta del Este
1
Punta del Este, Uruguay
— 3 nights
Drive
2
Montevideo, Uruguay
— 5 nights
Drive
3
Colonia del Sacramento, Uruguay
— 3 nights
+3
Bus to Puerto Madero, Taxi to El Palomar, Fly to Iguazu, Drive to Ciudad Del Este
4
Ciudad Del Este, Paraguay
— 3 nights
Bus to Ypacaraí, Taxi to Asuncion
5
Asuncion, Paraguay
— 4 nights
Fly

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Punta del Este, Uruguay — 3 nights

Monaco of South America

With plenty of modern casinos, well-developed beaches, chic restaurants, and upscale hotels, Punta del Este vacations draw visitors from Argentina, Brazil, and beyond.
Get out of town with these interesting Punta del Este side-trips: Playa Punta Ballena (in Punta Ballena), Piriapolis (Castillo de Piria & Cerro San Antonio) and Pan De Azucar (in Pan de Azucar). And it doesn't end there: explore the world behind art at Museo – Taller de Casapueblo, get outside with MAREAS Escuela de Buceo, don't miss a visit to Museo La Antigua Estacion, and snap pictures at Puente Leonel Viera.

For reviews, ratings, other places to visit, and tourist information, read our Punta del Este online driving holiday planner.

Groningen, The Netherlands to Punta del Este is an approximately 30-hour combination of flight and car. The time zone difference moving from Central European Standard Time (CET) to Uruguay Standard Time (UYT) is minus 4 hours. When traveling from Groningen in September, plan for little chillier days and about the same nights in Punta del Este: temperatures range from 19°C by day to 13°C at night. Cap off your sightseeing on the 8th (Fri) early enough to go by car to Montevideo.
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Outdoors · Museums · Parks · Beaches
Side Trips
Find places to stay Sep 5 — 8:

Montevideo, Uruguay — 5 nights

With a rich cultural scene and plenty of developed beaches, Montevideo vacations appeal to a growing number of visitors from around the world.
Explore Montevideo's surroundings by going to Pizzorno Family Estates (in Canelones) and Bodegas Castillo Viejo (in Las Piedras). There's much more to do: don't miss a visit to Plaza Independencia, go for a walk through Rambla de Montevideo, admire the landmark architecture of Palacio Salvo, and stop by Ciudad Vieja.

To see more things to do, photos, where to stay, and other tourist information, go to the Montevideo trip maker site.

Traveling by car from Punta del Este to Montevideo takes 2 hours. Alternatively, you can take a bus. In September, daily temperatures in Montevideo can reach 20°C, while at night they dip to 11°C. Finish your sightseeing early on the 13th (Wed) so you can drive to Colonia del Sacramento.
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Museums · Shopping · Neighborhoods · Wineries
Side Trips
Find places to stay Sep 8 — 13:

Colonia del Sacramento, Uruguay — 3 nights

Sleepy cobbled streets lined with pastel-colored houses lead down to the water in Colonia del Sacramento.
Change things up with these side-trips from Colonia del Sacramento: Carmelo (Bodega Campo Tinto, Bodega Boutique El Legado, &more). Next up on the itinerary: stop by Barrio Historico, pause for some serene contemplation at Iglesia Matriz, contemplate the waterfront views at Rio de la Plata, and enjoy the sea views from Colonia del Sacramento Lighthouse.

To find more things to do, reviews, maps, and more tourist information, use the Colonia del Sacramento trip builder app.

You can drive from Montevideo to Colonia del Sacramento in 2.5 hours. Alternatively, you can take a bus. In September, daytime highs in Colonia del Sacramento are 20°C, while nighttime lows are 12°C. Wrap up your sightseeing on the 16th (Sat) to allow time to travel to Ciudad Del Este.
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Wineries · Historic Sites · Museums · Nature
Side Trip
Find places to stay Sep 13 — 16:

Ciudad Del Este, Paraguay — 3 nights

Supermarket of South America

The commercial center of eastern Paraguay, busy Ciudad Del Este serves primarily as a shopping destination for Argentines and Brazilians.
Go for a jaunt from Ciudad Del Este to Hernandarias to see Refugio Tati Yupi about 42 minutes away. The adventure continues: take in the dramatic scenery at Saltos del Monday, make a trip to PRESA DE ITAIPU, buy something for everyone on your list at SAX, and fly down the slopes at Snow Park.

Plan a trip to Ciudad Del Este easily and quickly by telling Klarna Trips to suggest an itinerary.

Traveling by combination of bus, taxi, flight, and car from Colonia del Sacramento to Ciudad Del Este takes 7.5 hours. Alternatively, you can do a combination of ferry, bus, flight, and car; or drive. Traveling from Colonia del Sacramento in September, expect Ciudad Del Este to be somewhat warmer, temps between 32°C and 18°C. Wrap up your sightseeing on the 19th (Tue) to allow time to travel to Asuncion.
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Parks · Nature · Shopping · Wildlife
Side Trips
Find places to stay Sep 16 — 19:

Asuncion, Paraguay — 4 nights

Mother of Cities

Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.
Venture out of the city with trips to San Bernardino (Lago Ypacarai & Aventura Xtrema). There's still lots to do: take an in-depth tour of Casa de la Independencia, admire the masterpieces at Museo Etnografico Andres Barbero, take in nature's colorful creations at Botanical Garden and Zoo (Jardin Botanico y Zoologico), and stroll around Parque Nu Guasu.

To find photos, where to stay, reviews, and more tourist information, read Asuncion online tour itinerary maker.

Traveling by combination of bus and taxi from Ciudad Del Este to Asuncion takes 4.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Ciudad Del Este to Asuncion is minus 1 hour. In September, plan for daily highs up to 33°C, and evening lows to 19°C. On the 23rd (Sat), wrap the sightseeing up by early afternoon so you can travel back home.
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Parks · Museums · Nature · Tours
Side Trips
Find places to stay Sep 19 — 23:

Uruguay travel guide

4.2
Landmarks · Scenic Walking Areas · Art Museums
Switzerland of South America
One of the smallest countries in South America, tourist-friendly Uruguay is often called the "Switzerland of South America" because of its consistent economic development and progressive society. Open-minded Montevideo serves as the starting point of most Uruguay vacations, offering visitors an eclectic cultural scene and a chance to discover some of South America's major architectural treasures. Away from the cosmopolitan capital city, vacations in Uruguay involve exploring wildlife-rich areas along the Atlantic and touring the rustic interior on horseback, gaucho style. In this sports-loving country, the highlight of your Uruguay trip might just be a soccer match between Penarol and Nacional, the country's two major clubs.
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Paraguay travel guide

3.8
Heart of South America
Divided in half by its eponymous river, Paraguay is a land of contrasts, especially between its lush eastern region where most of the population lives and the arid west, filled with rustic villages and old Jesuit colonies. Although under Spanish rule for three centuries and with a recent history of dictatorships and wars, Paraguay retained its native Guarani culture, with more than 80 percent of population of indigenous heritage. You'll find plenty of things to do in Paraguay, from touring cosmopolitan cities and quaint Jesuit colonies, to browsing affordable arts and crafts stores and sailing on rivers that crisscross the diverse natural landscape that makes up this landlocked nation.
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