22 days in Chile Itinerary

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.

You'll find plenty of places to visit near Santiago: Concha y Toro (in Pirque) and River Rafting & Tubing (in San Jose de Maipo). There's lots more to do: stroll around Cerro Santa Lucia, admire the landmark architecture of Metropolitan Cathedral (Catedral Metropolitana), learn about winemaking at Vina Cousino Macul, and take in the pleasant sights at Plaza de Armas.

To see photos, reviews, where to stay, and other tourist information, refer to the Santiago trip planner.

Florence, Italy to Santiago is an approximately 20.5-hour combination of train and flight. The time zone difference moving from Central European Standard Time (CET) to Chile Standard Time (CLT) is minus 5 hours. Cap off your sightseeing on the 6th (Fri) early enough to catch the shuttle to Valle Nevado.

The largest ski zone in South America, Valle Nevado offers 2,800 hectares (7,000 acres) of skiable area in the El Plomo foothills near Santiago.

On the 7th (Sat), hit the slopes at Valle Nevado - Ski Resort Chile.

For ratings, reviews, where to stay, and other tourist information, you can read our Valle Nevado itinerary planner.

Traveling by shuttle from Santiago to Valle Nevado takes 1.5 hours. Alternatively, you can drive; or take a bus. On the 7th (Sat), wrap the sightseeing up by early afternoon so you can drive to Santa Cruz.

The Chilean city of Santa Cruz offers a view into the country's agricultural and pastoral heritage, with well-preserved colonial-era traditions and architecture.

Kick off your visit on the 8th (Sun): learn about winemaking at Clos Apalta, then learn about winemaking at Vina Montes, and then learn about winemaking at Viu Manent. Get ready for a full day of sightseeing on the 9th (Mon): do a tasting at Koyle Family Vineyards and then do a tasting at Vina Casa Silva.

For reviews, maps, other places to visit, and tourist information, read our Santa Cruz road trip site.

Getting from Valle Nevado to Santa Cruz by car takes about 3 hours. Other options: take a bus; or do a combination of bus and train. In October in Santa Cruz, expect temperatures between 24°C during the day and 9°C at night. Finish your sightseeing early on the 9th (Mon) to allow enough time to drive to Pucon.

Nestled in the shadow of the snow-capped Villarrica volcano, Pucon ranks among the world's premier destinations for adventure sports and high-thrills activities.

Start off your visit on the 10th (Tue): take in the architecture and atmosphere at Monasterio Santa Clara and then witness a stunning natural landmark at Termas Geometricas. On the 11th (Wed), you'll have a packed day of sightseeing: take in the dramatic scenery at Ojos del Caburga and then contemplate the waterfront views at Lake Villarrica.

Before you visit Pucon, use our trip planner to discover what you can do and see there.

Traveling by car from Santa Cruz to Pucon takes 7 hours. Alternatively, you can do a combination of bus and flight; or take a bus. Wrap up your sightseeing on the 11th (Wed) early enough to travel to Castro.

Main city on Chile's Chiloe Island, Castro represents one of the country's oldest inhabited settlements, making its fortune as both a tourist center and transportation hub.

Castro is known for sightseeing, shopping, and museums. Your trip includes some of its best attractions: admire the striking features of Church of San Francisco, browse the fresh offerings at Feria Campesina Yumbel, step off the mainland to explore Lemuy Island, and pause for some serene contemplation at Iglesia Nuestra Senora del Rosario.

Start your trip to Castro by creating a personalized itinerary on Klarna Trips.

You can do a combination of car and ferry from Pucon to Castro in 7 hours. Another option is to take a bus. In October, plan for daily highs up to 15°C, and evening lows to 5°C. Wrap up your sightseeing on the 14th (Sat) to allow time to travel to Puerto Varas.

Overlooking a lake, with a conical volcano looming in the background, Puerto Varas enjoys memorable scenery but retains its authentic atmosphere.

On the 15th (Sun), take in the dramatic scenery at Petrohué Waterfalls and then contemplate the waterfront views at Lago Todos Los Santos.

To find more things to do, maps, other places to visit, and other tourist information, read our Puerto Varas online road trip planner.

You can do a combination of ferry and car from Castro to Puerto Varas in 3.5 hours. Alternatively, you can take a bus. In October in Puerto Varas, expect temperatures between 17°C during the day and 5°C at night. Wrap up your sightseeing on the 15th (Sun) to allow time to fly to Valparaiso.

Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.

Start off your visit on the 16th (Mon): do a tasting at Matetic Vineyards and then learn about winemaking at Vinedos Veramonte. On the next day, examine the collection at La Sebastiana, get to know the fascinating history of Cerro Concepcion, and then don't miss a visit to Flower Clock (Reloj de Flores).

To see where to stay, more things to do, other places to visit, and more tourist information, read Valparaiso tour itinerary planning tool.

You can fly from Puerto Varas to Valparaiso in 3.5 hours. Other options are to drive; or take a bus. Prepare for somewhat warmer weather when traveling from Puerto Varas in October: high temperatures in Valparaiso hover around 20°C and lows are around 13°C. Finish your sightseeing early on the 17th (Tue) so you can fly to Copiapo.

Surrounded by the Atacama Desert, Copiapo receives very little rainfall and owes its existence to the mining industry.

On the 18th (Wed), pause for some photo ops at Monumento a Juan Godoy, then take in the architecture and atmosphere at Parroquia Nuestra Senora de la Candelaria, and then explore the fascinating landscape at Desierto Florido.

To see other places to visit, more things to do, reviews, and tourist information, refer to the Copiapo trip planner.

You can fly from Valparaiso to Copiapo in 3 hours. Other options are to drive; or take a bus. Cap off your sightseeing on the 18th (Wed) early enough to catch the flight to San Pedro de Atacama.

Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.

San Pedro de Atacama is known for nature, sightseeing, and parks. Your trip includes some of its best attractions: explore the striking landscape at Valle De La Luna, hunt for treasures at Feria Artesanal San Pedro de Atacama, tour the pleasant surroundings at Río Putana, and delve into the distant past at Pukara de Quitor.

To see other places to visit, traveler tips, where to stay, and more tourist information, refer to the San Pedro de Atacama trip app.

Fly from Copiapo to San Pedro de Atacama in 6 hours. Alternatively, you can drive; or take a bus. In October in San Pedro de Atacama, expect temperatures between 28°C during the day and 3°C at night. Finish your sightseeing early on the 21st (Sat) so you can travel back home.