44 days in South America Itinerary
Created using Klarna Trips South America trip maker
Start: London, United Kingdom
Fly
1
Cartagena, Colombia
— 4 nights
Fly
2
Medellin, Colombia
— 2 nights
Drive
3
Guatape, Colombia
— 2 nights
Fly
4
Bogota, Colombia
— 3 nights
Fly
5
Quito, Ecuador
— 5 nights
Fly
6
Iquitos, Peru
— 2 nights
Fly
7
Machu Picchu, Peru
— 3 nights
Fly
8
Uyuni, Bolivia
— 3 nights
Drive
9
Copiapo, Chile
— 4 nights
Drive
10
Buenos Aires, Argentina
— 6 nights
Fly
11
Montevideo, Uruguay
— 4 nights
Fly
12
Asuncion, Paraguay
— 2 nights
+3
Taxi to Ypacaraí, Bus to Ciudad del Este, Ferry to Puerto Iguazu, Bus to Iguazu National Park
13
Iguazu National Park, Argentina
— 3 nights
Bus to Foz do Iguacu, Fly to London
End: London, United Kingdom
Fri, Mar 10 - Sat, Apr 22
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Cartagena, Colombia — 4 nights

City of Heroes
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.You'll discover tucked-away gems like Plaza Santo Domingo and Templo de Santo Domingo. There's lots more to do: pause for some serene contemplation at Iglesia de la Trinidad, explore the historical opulence of Castillo de San Felipe de Barajas, appreciate the extensive heritage of Barrio Getsemani, and contemplate the long history of Sanctuary of Saint Peter Claver.
For other places to visit, ratings, reviews, and more tourist information, use the Cartagena trip builder tool.
London, UK to Cartagena is an approximately 17.5-hour flight. The time zone changes from Greenwich Mean Time (GMT) to Colombia Standard Time (COT), which is usually a -5 hour difference. In March, Cartagena is much warmer than London - with highs of 37°C and lows of 29°C. Finish up your sightseeing early on the 14th (Tue) so you can catch the flight to Medellin.
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Medellin, Colombia — 2 nights
City of the Eternal Spring
Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.On the 15th (Wed), see the sky in a new way at Planetario de Medellin, then make a trip to Escaleras Electricas De La Comuna 13, and then test the waters at a local thermal spa. On your second day here, get curious at Museo del Agua EPM, then see the interesting displays at Museo Casa de la Memoria, and then admire the striking features of Catedral Basilica Metropolitana de Medellin.
For where to stay, reviews, and tourist information, you can read our Medellin trip planner.
Fly from Cartagena to Medellin in 3 hours. Alternatively, you can drive; or take a bus. Plan for slightly colder temperatures traveling from Cartagena in March, with highs in Medellin at 32°C and lows at 21°C. Wrap up your sightseeing on the 16th (Thu) to allow time to drive to Guatape.
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Guatape, Colombia — 2 nights

On the shores of a large artificial lake, Guatape ensures a pleasant experience in a quiet little town known for its friendly residents and attractive architecture.Kick off your visit on the 17th (Fri): get to know the fascinating history of Parque Tematico Replica del Viejo Penol, then get out on two wheels at Guatape Motos, and then explore the striking landscape at Guatape Dam. On the 18th (Sat), you'll have a packed day of sightseeing: go for a stroll along the water at Lanchivas and then take in the dramatic natural features at Piedra Del Penol.
To see ratings, reviews, other places to visit, and tourist information, go to the Guatape trip maker website.
Traveling by car from Medellin to Guatape takes 2 hours. Alternatively, you can take a bus. In March, Guatape is a bit cooler than Medellin - with highs of 26°C and lows of 15°C. Wrap up your sightseeing on the 18th (Sat) early enough to fly to Bogota.
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Bogota, Colombia — 3 nights
Athens of South America
Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.Step off the beaten path and head to Iglesia de San Francisco and Catedral Primada de Bogota. Change things up with a short trip to Centro de Memoria El Cuartico in Valledupar (about 30 minutes away). There's much more to do: walk around Parque Metropolitano Simon Bolivar, browse the exhibits of Museo Santa Clara, examine the collection at Gold Museum (Museo del Oro), and explore the world behind art at Museo Botero del Banco de la Republica.
For other places to visit, ratings, where to stay, and tourist information, go to the Bogota travel site.
You can fly from Guatape to Bogota in 2.5 hours. Other options are to drive; or do a combination of taxi and bus. Traveling from Guatape in March, expect a bit cooler with lows of 10°C in Bogota. Finish up your sightseeing early on the 21st (Tue) so you can catch the flight to Quito.
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Quito, Ecuador — 5 nights

Light of America
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.Eschew the tourist crowds and head to Quito Old Town and Fundacion Iglesia de la Compania. There's still lots to do: take in the spiritual surroundings of Basilica del Voto Nacional, appreciate the history behind La Virgen del Panecillo, stroll around Parque Metropolitano, and admire the masterpieces at Casa Museo Guayasamin.
To find where to stay, maps, other places to visit, and more tourist information, go to the Quito visit planner.
Fly from Bogota to Quito in 5 hours. Alternatively, you can drive; or take a bus. Expect somewhat warmer evenings in Quito when traveling from Bogota in March, with lows around 18°C. On the 26th (Sun), wrap the sightseeing up by early afternoon so you can fly to Iquitos.
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Iquitos, Peru — 2 nights

Capital of the Peruvian Amazon
The largest city in the Peruvian Amazon and the world's largest metropolis unreachable by road, Iquitos represents a major starting point for river and rainforest adventures.Start off your visit on the 27th (Mon): stop by Centro Artesanal Turistico Anaconda, tour the pleasant surroundings at La Isla De Los Monos, and then stroll through Amazon Rescue Center. On your second day here, relax and rejuvenate at some of the best spas and then delve into the lush surroundings at Jairo Mejia Prado.
To see maps, photos, where to stay, and tourist information, go to the Iquitos sightseeing planning site.
Traveling by flight from Quito to Iquitos takes 10.5 hours. Traveling from Quito in March, expect Iquitos to be somewhat warmer, temps between 37°C and 26°C. Finish your sightseeing early on the 28th (Tue) so you can fly to Machu Picchu.
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Machu Picchu, Peru — 3 nights

A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.Explore hidden gems such as Jardin Botanico en Machu Pichu and Cascadas Allcamayo. The adventure continues: contemplate the long history of Santuario Historico de Machu Picchu, look for gifts at Arte Joyeria Rumi Wasi, and indulge in some personalized pampering at SPA Rocas Sagradas.
To see where to stay, more things to do, reviews, and more tourist information, refer to the Machu Picchu online travel planner.
You can fly from Iquitos to Machu Picchu in 6 hours. Alternatively, you can do a combination of taxi, ferry, and bus; or do a combination of ferry, bus, and train. Wrap up your sightseeing on the 31st (Fri) to allow time to fly to Uyuni.
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Uyuni, Bolivia — 3 nights
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.On the 1st (Sat), make a trip to Plaza Arce, head outdoors with Outdoor Activities, then take in the local highlights with Walking tours, and finally learn more about the world around you at Museo Arquecologia y Antropologico de los Andes Meridionales. Keep things going the next day: examine the collection at Train Cemetery, then take in the dramatic natural features at Salar de Uyuni, and then examine the collection at Museo de la Llama y la Sal.
Plan trip to Uyuni with our itinerary maker to find out where to go and what to do.
You can fly from Machu Picchu to Uyuni in 6.5 hours. Other options are to drive; or do a combination of train and bus. The time zone difference moving from Peru Standard Time (PET) to Bolivia Time (BOT) is 1 hour. In March, daily temperatures in Uyuni can reach 11°C, while at night they dip to 9°C. Finish your sightseeing early on the 3rd (Mon) so you can drive to Copiapo.
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Copiapo, Chile — 4 nights

Surrounded by the Atacama Desert, Copiapo receives very little rainfall and owes its existence to the mining industry.Step off the beaten path and head to Bahia Inglesa and Cerro Medanoso. Explore Copiapo's surroundings by going to Caldera (Faro de Punta Caldera & Playa Bahia Cisne). And it doesn't end there: admire the local landmark of Plaza Prat, hike along Cerro Bramador, contemplate the waterfront views at Laguna Verde, and try to win big at Antay Casino Hotel.
To find photos, ratings, where to stay, and more tourist information, read Copiapo online vacation builder.
Drive from Uyuni to Copiapo in 14.5 hours. Wrap up your sightseeing on the 7th (Fri) to allow time to drive to Buenos Aires.
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Buenos Aires, Argentina — 6 nights

Queen of La Plata
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.You'll discover tucked-away gems like Parque 3 de Febrero and Room Escape Games. You'll find plenty of places to visit near Buenos Aires: Catedral de San Isidro (in San Isidro) and La Plata (Plaza Moreno, Museo de La Plata, &more). Next up on the itinerary: contemplate the waterfront views at Lagos de Palermo, examine the collection at Buque Museo Fragata ARA Presidente Sarmiento, take in the architecture and atmosphere at Basilica del Santisimo Sacramento, and admire the landmark architecture of Mafalda Statue.
To see reviews, traveler tips, other places to visit, and other tourist information, refer to the Buenos Aires online route maker.
Getting from Copiapo to Buenos Aires by car takes about 22 hours. The time zone changes from Chile Standard Time to Argentina Standard Time, which is usually a 1 hour difference. Expect a daytime high around 26°C in April, and nighttime lows around 19°C. Wrap up your sightseeing on the 13th (Thu) early enough to fly to Montevideo.
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Montevideo, Uruguay — 4 nights

With a rich cultural scene and plenty of developed beaches, Montevideo vacations appeal to a growing number of visitors from around the world.Explore hidden gems such as Pizzorno Family Estates and Mirador Panoramico de Montevideo. Take a break from Montevideo with a short trip to Varela Zarranz Winery in Canelones, about 36 minutes away. Next up on the itinerary: take in the architecture and atmosphere at Iglesia de las Carmelitas, visit Ciudad Vieja, take in the pleasant sights at Rambla de Montevideo, and explore the world behind art at Centro Municipal de Exposiciones SUBTE.
To find reviews, other places to visit, where to stay, and more tourist information, use the Montevideo online sightseeing planner.
Getting from Buenos Aires to Montevideo by flight takes about 3 hours. Other options: ride a ferry; or do a combination of bus and car. In April in Montevideo, expect temperatures between 26°C during the day and 16°C at night. Cap off your sightseeing on the 17th (Mon) early enough to catch the flight to Asuncion.
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Asuncion, Paraguay — 2 nights

Mother of Cities
Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.Kick off your visit on the 18th (Tue): explore the galleries of Casa de la Independencia, then appreciate the history behind The National Pantheon of Heroes and Oratory of the Virgin Our Lady Saint Mary of the Asuncion, then ponder the world of politics at Palacio de López, and finally make a trip to Plaza de los Desaparecidos. On the 19th (Wed), you'll have a packed day of sightseeing: admire the striking features of Torre Icono, take an in-depth tour of Gran Hotel del Paraguay, and then stroll around Parque Nu Guasu.
To find maps, photos, more things to do, and other tourist information, refer to the Asuncion online holiday planner.
Getting from Montevideo to Asuncion by flight takes about 5.5 hours. Other options: take a bus; or drive. The time zone difference moving from Uruguay Standard Time to Paraguay Standard Time is minus 1 hour. Traveling from Montevideo in April, things will get a bit warmer in Asuncion: highs are around 34°C and lows about 22°C. Finish your sightseeing early on the 19th (Wed) so you can travel to Iguazu National Park.
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Iguazu National Park, Argentina — 3 nights

Iguazu National Park contains 672 sq km (259 sq mi) of fertile subtropical forests, but its main attraction is the majestic Iguazu Falls.On the 20th (Thu), take in the dramatic scenery at Iguazu Falls. On the next day, explore the activities along Lago Urugua-i, take in the dramatic scenery at Salto Bernabe Mendez, and then step off the mainland to explore Isla San Martin.
To find more things to do, photos, other places to visit, and tourist information, read our Iguazu National Park tour planning website.
Do a combination of taxi, bus, and ferry from Asuncion to Iguazu National Park in 6 hours. Alternatively, you can drive; or take a bus. The time zone changes from Paraguay Standard Time (PYT) to Argentina Standard Time (ART), which is usually a 1 hour difference. In April in Iguazu National Park, expect temperatures between 32°C during the day and 19°C at night. Wrap up your sightseeing on the 22nd (Sat) to allow time to travel back home.
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Ecuador travel guide
With abundant opportunities to discover fascinating World Heritage Sites, a holiday in Ecuador remains among the most culturally enriching travel experiences. Home to the world's highest active volcano, this little country packs a big punch when it comes to tourist activities. Some of the most popular things to do in Ecuador include visits to its astonishingly biodiverse wilderness areas, home to some 1,500 bird species, 840 species of amphibians and reptiles, and nearly 20,000 plant species. Of course, the highlight of many Ecuador vacations is bound to be the Galapagos Islands, made famous by naturalist Charles Darwin. Aside from the stunning nature, Ecuador also boasts many historic cities filled with photogenic colonial-era churches, mansions, and plazas.
Peru travel guide
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.
Bolivia travel guide
Tibet of the Americas
If you're an adventurous tourist, consider adding a Bolivia vacation to your travel itinerary. A land of rainforests, Andean glaciers, high altitude cities, and rushing rivers, Bolivia remains one of the most remote countries in the Western Hemisphere. With 60 percent of the population made up of indigenous peoples, native cultures permeate thecountry's music, architecture, and arts, as well as local folklore and traditions. Traveling in Bolivia you can experience diverse wildlife and ecosystems, learn about the country's rich history, try out its distinctive cuisine, and practice your Spanish with the locals, known for their clean and easy-to-understand accent.
Chile travel guide
Land of Poets
Squeezed between the Andes and the Pacific Ocean, geographically diverse Chile is a long, thin stretch of land encompassing some of the world's driest deserts in the north, and some of its largest glacial fields in the south. Though most Chile holidays include some form of adventure in the vast wilderness areas, the country also contains charming cities providing plenty of urban things to do and see. Many tours of Chile include at least a brief visit to the country's lush wine regions, where backyard vineyards compete with sprawling estates producing some of the world's most respected whites and reds.
Argentina travel guide
Land of Contrasts
Home to the highest and lowest points in South America, diverse Argentina enthralls visitors with its contrasting landscapes and rich cultural heritage. A tour of Argentina reveals a sprawling land of fiercely proud and hardworking gauchos, the legendary cowboys of South America's pampas. A vacation in Argentina also leads you to giant urban centers, filled with modern tourist attractions that include fine restaurants, award-winning museums, and renowned public parks, gardens, and zoos. Away from big cities, Argentina sightseeing combines visits to mighty waterfalls situated inside World Heritage-listed national parks in the north of the country, with excursions to icy glaciers in the south.
Uruguay travel guide
Switzerland of South America
One of the smallest countries in South America, tourist-friendly Uruguay is often called the "Switzerland of South America" because of its consistent economic development and progressive society. Open-minded Montevideo serves as the starting point of most Uruguay vacations, offering visitors an eclectic cultural scene and a chance to discover some of South America's major architectural treasures. Away from the cosmopolitan capital city, vacations in Uruguay involve exploring wildlife-rich areas along the Atlantic and touring the rustic interior on horseback, gaucho style. In this sports-loving country, the highlight of your Uruguay trip might just be a soccer match between Penarol and Nacional, the country's two major clubs.
Paraguay travel guide
Heart of South America
Divided in half by its eponymous river, Paraguay is a land of contrasts, especially between its lush eastern region where most of the population lives and the arid west, filled with rustic villages and old Jesuit colonies. Although under Spanish rule for three centuries and with a recent history of dictatorships and wars, Paraguay retained its native Guarani culture, with more than 80 percent of population of indigenous heritage. You'll find plenty of things to do in Paraguay, from touring cosmopolitan cities and quaint Jesuit colonies, to browsing affordable arts and crafts stores and sailing on rivers that crisscross the diverse natural landscape that makes up this landlocked nation.