50 days in South America Itinerary

Created using Klarna Trips South America journey builder
Make it your trip
Fly
1
Buenos Aires, Argentina
— 5 nights
Bus
2
Punta del Este, Uruguay
— 3 nights
Fly
3
Salvador, Brazil
— 15 nights
Fly
4
Cartagena, Colombia
— 6 nights
+2
Fly to Baltra Island, Ferry to Santa Cruz Ferry Terminal, Bus to Puerto Ayora
5
Puerto Ayora, Ecuador
— 4 nights
+2
Ferry to San Cristobal, Fly to Baltra Island, Fly to Cusco
6
Cusco, Peru
— 5 nights
Fly to La Paz, Shuttle to Copacabana
7
Copacabana, Bolivia
— 6 nights
Drive

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Buenos Aires, Argentina — 5 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Get outdoors at Parque 3 de Febrero and Reserva Ecologica. You'll discover tucked-away gems like Palacio de Aguas Corrientes and Basilica de Nuestra Senora Del Pilar. Explore the numerous day-trip ideas around Buenos Aires: La Plata (Plaza Moreno & Estadio Ciudad de La Plata). There's still lots to do: make a trip to Cementerio de la Recoleta, get to know the fascinating history of Calle Defensa, take a stroll through Puerto Madero, and get a taste of the local shopping with Palermo.

To see photos, reviews, and other tourist information, go to the Buenos Aires trip maker.

Santiago, Chile to Buenos Aires is an approximately 5.5-hour flight. You can also drive; or take a bus. Traveling from Santiago to Buenos Aires, you'll lose 1 hour due to the time zone difference. October in Buenos Aires sees daily highs of 69°F and lows of 58°F at night. Wrap up your sightseeing on the 22nd (Sat) early enough to fly to Punta del Este.
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Side Trip
Find places to stay Oct 17 — 22:

Punta del Este, Uruguay — 3 nights

Monaco of South America

With plenty of modern casinos, well-developed beaches, chic restaurants, and upscale hotels, Punta del Este vacations draw visitors from Argentina, Brazil, and beyond.
You'll get in some beach time at Playa La Moza and Playa Montoya. Get outdoors at Arboretum Lussich and Playa Mansa. There's much more to do: explore the world behind art at Ralli Museum Punta del Este, see some colorful creatures with a scuba or snorkeling tour, snap pictures at Puente Leonel Viera, and browse the exhibits of Museo – Taller de Casapueblo.

For other places to visit, photos, where to stay, and other tourist information, go to the Punta del Este road trip planner.

Take a bus from Buenos Aires to Punta del Este in 8 hours. Alternatively, you can fly; or do a combination of ferry and taxi; or do a combination of ferry and bus. When traveling from Buenos Aires in October, plan for little chillier days in Punta del Este, with highs around 64°F, while nights are about the same with lows around 56°F. Finish up your sightseeing early on the 25th (Tue) so you can catch the flight to Salvador.
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Outdoors · Parks · Beaches · Wildlife
Side Trips
Find places to stay Oct 22 — 25:

Salvador, Brazil — 15 nights

Black Rome

Nowhere are the traditions of Brazil's African-background community as strong as in Salvador, the colorful, historical capital of Bahia state.
Escape the urban bustle at Ilha dos Frades and Vilas do Atlantico Beach. Do some cultural sightseeing at Sister Dulce memorial and Casa do Rio Vermelho. Change things up with these side-trips from Salvador: Ipitanga Beach (in Lauro de Freitas), Itacimirim Beach (in Itacimirim) and Guarajuba Beach (in Guarajuba). There's much more to do: enjoy the sand and surf at Flamengo Beach, take in the architecture and atmosphere at Basilica Do Senhor Do Bonfim, stroll through Stella Maris Beach, and visit Pelourinho.

To see maps, traveler tips, where to stay, and tourist information, you can read our Salvador trip itinerary builder tool.

Traveling by flight from Punta del Este to Salvador takes 10 hours. Alternatively, you can drive; or take a bus. Traveling from Punta del Este in October, things will get a bit warmer in Salvador: highs are around 83°F and lows about 74°F. Finish up your sightseeing early on the 10th (Thu) so you can catch the flight to Cartagena.
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Side Trips
Find places to stay Oct 26 — Nov 10:

Cartagena, Colombia — 6 nights

City of Heroes

The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Eschew the tourist crowds and head to Scuba & Snorkeling and Sanctuary of Saint Peter Claver. Get outdoors at Boats4U and Playa Blanca. Go for a jaunt from Cartagena to Islas de Rosario to see Oceanario about 1h 35 min away. Next up on the itinerary: pause for some serene contemplation at Iglesia de la Trinidad, admire the masterpieces at Arte Moderno Museo de Arte Moderno de Cartagena, don't miss a visit to Centro de Convenciones Cartagena de Indias, and ponder the world of politics at Alcaldia Mayor.

For reviews, where to stay, photos, and tourist information, read Cartagena day trip planning app.

Traveling by flight from Salvador to Cartagena takes 16 hours. The time zone difference when traveling from Salvador to Cartagena is minus 2 hours. In November, daytime highs in Cartagena are 89°F, while nighttime lows are 78°F. Wrap up your sightseeing on the 17th (Thu) to allow time to travel to Puerto Ayora.
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Side Trips
Find places to stay Nov 11 — 17:

Puerto Ayora, Ecuador — 4 nights

The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
You'll get in some beach time at Galapagos Beach at Tortuga Bay and Playa de los Alemanes. Explore hidden gems such as Las Grietas and Metropolitan Touring. The adventure continues: see some colorful creatures with a scuba or snorkeling tour, don't miss a visit to Santa Cruz Fish Market, view the masterpieces at Samay Latin Art, and stroll through El Chato - Giant Tortoise Reserve.

For more things to do, reviews, traveler tips, and tourist information, go to the Puerto Ayora tour itinerary planner.

Do a combination of flight, ferry, and bus from Cartagena to Puerto Ayora in 12.5 hours. Traveling from Cartagena in November, expect Puerto Ayora to be a bit cooler, temps between 80°F and 71°F. Finish your sightseeing early on the 22nd (Tue) to allow enough time to travel to Cusco.
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Parks · Wildlife · Outdoors · Nature
Side Trips
Find places to stay Nov 17 — 22:

Cusco, Peru — 5 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Take a break from the city and head to Santuario Animal de Cochahuasi and Horseback Riding Tours. Satisfy your inner culture vulture at Sacsayhuaman and River Rafting & Tubing. There's much more to do: delve into the distant past at Q'enqo, steep yourself in history at Plaza de Armas, pause for some serene contemplation at Iglesia de la Compania de Jesus, and soothe aching muscles at some of the top local wellness centers.

To find ratings, where to stay, photos, and tourist information, use the Cusco trip itinerary maker tool.

You can do a combination of ferry and flight from Puerto Ayora to Cusco in 20.5 hours. Alternatively, you can do a combination of bus, ferry, and flight. Expect slightly colder weather when traveling from Puerto Ayora in November: highs in Cusco hover around 72°F, while lows dip to 45°F. Finish your sightseeing early on the 28th (Mon) to allow enough time to travel to Copacabana.
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Historic Sites · Tours · Outdoors · Spas
Side Trip
Find places to stay Nov 23 — 28:

Copacabana, Bolivia — 6 nights

The town of Copacabana represents the largest Bolivian settlement on the shore of Lake Titicaca, the largest lake in the continent.
Step off the beaten path and head to Isla del Sol and Cerro Calvario. Do some cultural sightseeing at Basilica of Our Lady of Copacabana and Museo del Poncho. Next up on the itinerary: explore the striking landscape at Horca del Inca, stop by The Spitting Llama Bookstore & Outfitter, make a trip to Avenida 6 de Agosto, and head off the coast to Isla De La Luna.

To see reviews, where to stay, traveler tips, and more tourist information, read Copacabana travel planner.

Do a combination of flight and shuttle from Cusco to Copacabana in 7 hours. Alternatively, you can do a combination of flight and bus; or drive. Due to the time zone difference, you'll lose 1 hour traveling from Cusco to Copacabana. On the 4th (Sun), you'll travel back home.
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Nature · Parks · Historic Sites · Trails
Find places to stay Nov 28 — Dec 4:

Uruguay travel guide

4.2
Landmarks · Scenic Walking Areas · Art Museums
Switzerland of South America
One of the smallest countries in South America, tourist-friendly Uruguay is often called the "Switzerland of South America" because of its consistent economic development and progressive society. Open-minded Montevideo serves as the starting point of most Uruguay vacations, offering visitors an eclectic cultural scene and a chance to discover some of South America's major architectural treasures. Away from the cosmopolitan capital city, vacations in Uruguay involve exploring wildlife-rich areas along the Atlantic and touring the rustic interior on horseback, gaucho style. In this sports-loving country, the highlight of your Uruguay trip might just be a soccer match between Penarol and Nacional, the country's two major clubs.
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Colombia travel guide

4.2
Diverse in terms of landscapes, climates, and cultures, Colombia remains one of South America's least explored tourist destinations, overshadowed by its more popular southern neighbors. Combining the best of what the continent has to offer, a vacation in Colombia allows you to blend outdoor adventures with tours of picture-perfect cobblestoned towns dating back to the colonial era. Tourists on a Colombia holiday can easily hop from sun-kissed coastal spots to the hilly coffee-growing region, where thriving plantations quickly give way to a landscape of snow-covered volcanic peaks and the paramo--alpine ecosystems sheltering some of the rarest plants growing above the continuous forest line.
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Ecuador travel guide

4.5
With abundant opportunities to discover fascinating World Heritage Sites, a holiday in Ecuador remains among the most culturally enriching travel experiences. Home to the world's highest active volcano, this little country packs a big punch when it comes to tourist activities. Some of the most popular things to do in Ecuador include visits to its astonishingly biodiverse wilderness areas, home to some 1,500 bird species, 840 species of amphibians and reptiles, and nearly 20,000 plant species. Of course, the highlight of many Ecuador vacations is bound to be the Galapagos Islands, made famous by naturalist Charles Darwin. Aside from the stunning nature, Ecuador also boasts many historic cities filled with photogenic colonial-era churches, mansions, and plazas.
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Peru travel guide

4.6
Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.
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Bolivia travel guide

4.3
Landmarks · Geologic Formations · Specialty Museums
Tibet of the Americas
If you're an adventurous tourist, consider adding a Bolivia vacation to your travel itinerary. A land of rainforests, Andean glaciers, high altitude cities, and rushing rivers, Bolivia remains one of the most remote countries in the Western Hemisphere. With 60 percent of the population made up of indigenous peoples, native cultures permeate thecountry's music, architecture, and arts, as well as local folklore and traditions. Traveling in Bolivia you can experience diverse wildlife and ecosystems, learn about the country's rich history, try out its distinctive cuisine, and practice your Spanish with the locals, known for their clean and easy-to-understand accent.
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