6 days in Jacksonville & San Antonio Itinerary

The sprawling city of Jacksonville is not only Florida's most populous city, but also the largest city by land area in the continental United States.

Venture out of the city with trips to DeLand (Blue Heron River Tours Inc & Stetson Mansion) and St. Augustine (St. George Street, Flagler College, &more). Next up on the itinerary: identify plant and animal life at Catty Shack Ranch Wildlife Sanctuary, indulge your taste buds at Food & Drink, learn about wildlife with up-close encounters at Jacksonville Zoo & Gardens, and explore the world behind art at The Cummer Museum of Art & Gardens.

To find ratings, traveler tips, reviews, and tourist information, read our Jacksonville trip itinerary maker.

Use the Route module to find travel options from your starting location to Jacksonville. In December, plan for daily highs up to 72°F, and evening lows to 50°F. Finish your sightseeing early on the 26th (Tue) so you can fly to San Antonio.

As the state’s second largest city, San Antonio embodies Texas’ rich cultural heritage while maintaining the Old West charm of an oil town.

On the 27th (Wed), take in the architecture and atmosphere at San Fernando De Bexar Cathedral, contemplate the long history of Mission San Jose, examine the collection at San Antonio Fire Museum, then get engrossed in the history at The Alamo, and finally shop like a local with The San Antonio River Walk.

To find ratings, other places to visit, and tourist information, read our San Antonio tour planner.

You can fly from Jacksonville to San Antonio in 6 hours. Alternatively, you can drive; or take a bus. The time zone changes from Eastern Standard Time (EST) to Central Standard Time (CST), which is usually a -1 hour difference. When traveling from Jacksonville in December, plan for little chillier days in San Antonio, with highs around 66°F, while nights are about the same with lows around 47°F. Cap off your sightseeing on the 27th (Wed) early enough to travel back home.