6 days in North Carolina Itinerary

The center of Cherokee culture in the eastern part of the country, the town named after this Native American tribe serves as a base camp for hiking in the Great Smoky Mountains.

Kick off your visit on the 29th (Sat): brush up on your knowledge of spirits at Elevated Mountain Distilling Co., contemplate the long history of Oconaluftee Indian Village, then see the interesting displays at Museum of the Cherokee Indian, and finally try your luck at Casino at Harrah’s Cherokee.

To see more things to do, ratings, maps, and more tourist information, you can read our Cherokee itinerary planner.

Philadelphia to Cherokee is an approximately 3.5-hour flight. You can also drive; or do a combination of train, bus, and car. Traveling from Philadelphia in October, Cherokee is a bit cooler at night with lows of 44°F. Finish your sightseeing early on the 29th (Sat) so you can drive to Asheville.

Asheville nestles between two major mountain ranges in the scenic western section of North Carolina.

On the 30th (Sun), take a stroll through River Arts District, indulge your thirst for a good beer at Sierra Nevada Brewing Co. Tours & Tastings, then do a tasting at Saint Paul Mountain Vineyards, and finally explore the wealth of natural beauty at The North Carolina Arboretum. Get ready for a full day of sightseeing on the next day: savor the flavors at Food & Drink, get a taste of the local shopping with Woolworth Walk, and then relax and rejuvenate at some of the best spas.

For traveler tips, other places to visit, reviews, and tourist information, use the Asheville day trip planning site.

Traveling by car from Cherokee to Asheville takes 1.5 hours. October in Asheville sees daily highs of 70°F and lows of 47°F at night. Cap off your sightseeing on the 31st (Mon) early enough to catch the flight to Wilmington.

Holiday in Willington to discover a charming coastal city filled with azalea gardens, historical neighborhoods, and cozy cafes.

On the 1st (Tue), stop by Historic District, learn about winemaking at Noni Bacca Winery, and then enjoy the sand and surf at Wrightsville Beach Municipal Complex.

To see ratings, where to stay, photos, and tourist information, read our Wilmington trip maker app.

Getting from Asheville to Wilmington by flight takes about 4.5 hours. Other options: drive; or take a bus. Traveling from Asheville in October, things will get somewhat warmer in Wilmington: highs are around 77°F and lows about 57°F. Finish your sightseeing early on the 1st (Tue) to allow enough time to drive to Kill Devil Hills.

Kill Devil Hills is a town in Dare County, North Carolina. Kick off your visit on the 2nd (Wed): contemplate the long history of Wright Brothers National Memorial, kick back and relax at Pea Island National Wildlife Refuge, and then brush up on your knowledge of spirits at Outer Banks Distilling. On the 3rd (Thu), you'll have a packed day of sightseeing: enjoy the sand and surf at Currituck Beach, take an exotic tour of Back Country Safari Tours, and then visit a coastal fixture at Currituck Beach Lighthouse and Museum.

To see where to stay, maps, other places to visit, and tourist information, refer to the Kill Devil Hills trip planning website.

Traveling by car from Wilmington to Kill Devil Hills takes 5 hours. Alternatively, you can fly; or do a combination of bus and taxi. Traveling from Wilmington in November, expect nights in Kill Devil Hills to be about the same, around 48°F, while days are a bit cooler, around 61°F. Finish your sightseeing early on the 3rd (Thu) to allow enough time to fly back home.