8 days in North Carolina Piedmont Itinerary

Once the seat of a thriving tobacco industry, Durham has seen some significant moments in American history.

Start off your visit on the 24th (Fri): steep yourself in history at Historic Yates Mill County Park, then look for all kinds of wild species at Hemlock Bluffs Nature Preserve, and then identify plant and animal life at Carolina Tiger Rescue. Keep things going the next day: examine the collection at The Carolina Basketball Museum, look for all kinds of wild species at Conservators Center, and then admire the majestic nature at Eno River State Park.

To find traveler tips, maps, where to stay, and tourist information, read our Durham trip itinerary app.

Indianapolis to Durham is an approximately 3.5-hour flight. You can also drive; or take a bus. Expect a bit warmer temperatures when traveling from Indianapolis in February; daily highs in Durham reach 55°F and lows reach 35°F. Wrap up your sightseeing on the 25th (Sat) early enough to drive to Winston Salem.

Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. You'll explore and learn at North Carolina Transportation Museum and Children's Museum of Winston-Salem. Explore hidden gems such as Salem God's Acre Cemetery and Childress Vineyards. Venture out of the city with trips to Dobson (Stony Knoll Vineyards & Shelton Vineyards), JOLO Winery & Vineyards (in Pilot Mountain) and International Civil Rights Center & Museum (in Greensboro). The adventure continues: learn about winemaking at RayLen Vineyards.

To find where to stay, maps, reviews, and other tourist information, you can read our Winston Salem trip itinerary builder.

Traveling by car from Durham to Winston Salem takes 1.5 hours. Alternatively, you can take a bus; or do a combination of train and bus. In February, daytime highs in Winston Salem are 52°F, while nighttime lows are 34°F. Wrap up your sightseeing on the 28th (Tue) to allow time to drive to Charlotte.

A rapidly growing city in central North Carolina, Charlotte is the state's largest urban center and a major regional hub for finance, industry, technology, and entertainment.

Appreciate the collections at NASCAR Hall of Fame and Discovery Place Kids-Huntersville. Discover out-of-the-way places like Morrow Mountain State Park and The Schiele Museum of Natural History. Step out of Charlotte to go to Albemarle and see Dennis Vineyards Winery, which is approximately 56 minutes away. There's lots more to do: savor the flavors at Food & Drink, take a stroll through SouthPark, brush up on your knowledge of spirits at Muddy River Distillery, and get curious at Carolina Raptor Center.

For ratings, maps, other places to visit, and other tourist information, read our Charlotte day trip planning app.

Getting from Winston Salem to Charlotte by car takes about 1.5 hours. Other options: drive; or take a bus. In February, plan for daily highs up to 57°F, and evening lows to 36°F. Wrap up your sightseeing on the 3rd (Fri) to allow time to fly back home.